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Keratoacanthoma with perineural invasion: A report of 40 cases

โœ Scribed by Amanda M Godbolt; John J Sullivan; David Weedon

Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
108 KB
Volume
42
Category
Article
ISSN
0004-8380

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โœฆ Synopsis

SUMMARY

Keratoacanthoma is a unique clinicopathological entity, despite a recent trend to regard it as a variant of squamous cell carcinoma. The occurrence of perineural invasion is an uncommon phenomenon in keratoacanthomas, with a predilection for lesions on the face. We studied a series of 40 cases of keratoacanthoma in which perineural invasion occurred. Of the 40 cases, 27 were from the head or neck region. We found no metastasis or direct death attributable to the presence of perineural invasion in the 35 cases in our series for whom followโ€up data were available. In only one case did local recurrence occur and this was not considered by the authors to be directly attributable to the presence of perineural invasion. These findings add further support to the notion that keratoacanthoma is biologically different from squamous cell carcinoma.

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