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Keratinocyte stimulation of matrix metalloproteinase-1 production and proliferation in fibroblasts: regulation through mitogen-activated protein kinase signalling events

✍ Scribed by Moon, S E; Bhagavathula, N; Varani, J

Book ID: 109997331
Publisher: Nature Publishing Group
Year: 2002
Tongue: English
Weight: 152 KB
Volume: 87
Category: Article
ISSN: 0007-0920
DOI: 10.1038/sj.bjc.6600478

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## Abstract Blood vessel injury results in limited oxygen tension and diffusion leading to hypoxia, increased anaerobic metabolism, and elevated production of acidic metabolites that cannot be easily removed due to the reduced blood flow. Therefore, an acidic extracellular pH occurs in the local mi