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Keratan sulfate content and articular cartilage maturation during postnatal rabbit growth

✍ Scribed by Jon R. Zirn; David J. Schurman; Dr. R. Lane Smith

Book ID: 102911512
Publisher: Elsevier Science
Year: 1984
Tongue: English
Weight: 611 KB
Volume: 2
Category: Article
ISSN: 0736-0266
DOI: 10.1002/jor.1100020205

No coin nor oath required. For personal study only.

✦ Synopsis

This article describes the macromolecular changes in keratan sulfate and proteoglycan that occur in rabbit articular cartilage during postnatal development. Articular cartilage glycosaminoglycans from femoral condyles and the tibial plateaus of rabbits at 8, 12, 18, and 26 weeks and 2 years of age were extracted, fractionated, and quantified. The predominant glycosaminoglycan present in articular cartilage at 8 weeks was chondroitin sulfate. During subsequent maturation the relative proportions of keratan sulfate and chondroitin sulfate varied inversely. The greatest increase in the amount of keratan sulfate present in cartilage was observed between 12 and 26 weeks of age. Hyaluronic acid content was measurable at 12 weeks; afterward the amount remained relatively constant with age. Proteoglycans, extracted from 6-, 12-, and 22-week-old rabbit femoral and tibial cartilage in the presence of protease inhibitors, were analyzed on columns of Sepharose CL-2B. Cartilage proteoglycans decreased in hydrodynamic size between 12 and 22 weeks, corresponding to the period of maximal change in content of keratan and chondroitin sulfate.

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