Karyotypic pattern of pancreatic adenocarcinomas correlates with survival and tumour grade

✍ Scribed by Bertil Johansson; Georgia Bardi; Nikos Pandis; Ludmila Gorunova; Pia Lena Bäckman; Nils Mandahl; Sigmund Dawiskiba; åke Andrén-Sandberg; Sverre Heim; Felix Mitelman

• Publisher: John Wiley and Sons
• Year: 1994
• Tongue: French
• Weight: 521 KB
• Volume: 58
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/ijc.2910580103

✦ Synopsis

The relationship between cytogenetic findings and clinicohistopathological parameters was assessed in 29 patients with pancreatic adenocarcinoma. Karyotypic analysis revealed normal karyotypes (N) in 8 carcinomas and abnormal karyotypes (A) in 2 I. Within the A group, 8 cases had simple chromosome abnormalities (As), i.e., only one numerical or structural aberration, whereas I 3 had complex changes with multiple numerical and structural abnormalities (Ac). No significant differences between the N and A groups were detected in terms of tumour grade, clinical stage, type of surgery performed, tumour site or size or the patient's age and survival. A correlation analysis between groups As and Ac revealed a significant difference with regard to grade, poorly differentiated carcinomas being more frequent in the Ac group. Patients in the Ac group had also a significantly shorter survival time than those in the As group. None of the other potentially prognostic parameters, i.e., grade, tumour site, stage and type of surgery performed, correlated significantly with clinical outcome.