Karyotypic changes in three human primary malignant melanomas
✍ Scribed by Jens Jørgen Elberg; Mogens Rønne
- Book ID
- 119104405
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- English
- Weight
- 98 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0165-4608
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Fifteen malignant melanomas were subjected to chromosomal analysis, in order to determine whether the number of chromosomes in a tumor cell could be correlated to a clinical prognosis. The protocol involved a direct technique which utilized a Colcemid blockade of spindle formation in mitosis to allo
## Abstract Malignant melanomas can be divided into two major subtypes, involving either the skin or eye melanomas. Both tumor forms exhibit highly complex karyotypes with nonrandom recurrent chromosomal imbalances. Loss of chromosome 3, the short arm of chromosome 1, and gain of 8q have been sugge