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Karyotype is an independent prognostic parameter in therapy-related acute myeloid leukemia (t-AML): an analysis of 93 patients with t-AML in comparison to 1091 patients with de novo AML

✍ Scribed by Schoch, C; Kern, W; Schnittger, S; Hiddemann, W; Haferlach, T


Book ID
110055715
Publisher
Nature Publishing Group
Year
2003
Tongue
English
Weight
166 KB
Volume
18
Category
Article
ISSN
0887-6924

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## Abstract The __AML1__ gene (also known as __RUNX1__) at 21q22 codes for core binding factor (CBF) Ξ±, which forms a heterodimer with CBF Ξ² that acts as a transcriptional activating factor. CBF is a critical regulator in the generation and differentiation of definitive hematopoietic stem cells and