✍ Scribed by Capucine Picard; Fethi Mellouli; Renan Duprez; Gaëlle Chédeville; Bénédicte Neven; Sylvie Fraitag; Jean Delaunay; Françoise Le Deist; Alain Fischer; Stéphane Blanche; Christine Bodemer; Antoine Gessain; Jean-Laurent Casanova; Mohamed Bejaoui
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A boy with Wiskott-Aldrich syndrome suffered from thymidine kinase (TK)-altered and aciclovir-resistant herpes simplex virus type 1 (HSV-1) skin infections. He presented with severe herpes simplex around the left eye in March 1993 at the age of 8 years. HSV-1 strain TAS was isolated and was shown to
Epstein-Barr virus (EBV) DNA was detected in immunoblastic lymphoma arising in a child with the primary immunodeficiency, Wiskott-Aldrich syndrome. Southern blot analysis of the structure of the EBV genome revealed that the lymphoma was monoclonal and contained episomal EBV DNA. The EBV latent genes