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Kaposi's sarcoma herpesvirus–associated Castleman's disease with POEMS syndrome

✍ Scribed by Dong-Eog Kim; Ho Jin Kim; Young A. Kim; Kwang-Woo Lee

Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
186 KB
Volume
23
Category
Article
ISSN
0148-639X

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✦ Synopsis

The pathogenic link between POEMS (polyneuropathy, organomegaly, endocrinopathy, M protein, skin changes, and various other clinical signs) syndrome and Castleman's disease is unclear. Roles for M protein in POEMS syndrome and cytokines in systemic manifestations of multicentric Castleman's disease have been suggested. Recently, pathogenic roles of cytokines in POEMS syndrome and Kaposi's sarcomaassociated herpesvirus (KSHV) in Castleman's disease have been reported. We report on a patient with KSHV-associated Castleman's disease with POEMS syndrome, and suggest a possible role of KSHV in initiating and linking these two diseases.

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