Kansuinone, a novel euphane-type triterpene from Euphorbia kansui

✍ Scribed by Jie Guo; Hong-Ping He; Xin Fang; Ying-Tong Di; Shun-Lin Li; Zhen Zhang; Ying Leng; Hui-Ming Hua; Xiao-Jiang Hao

• Publisher: Elsevier Science
• Year: 2010
• Tongue: French
• Weight: 502 KB
• Volume: 51
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/j.tetlet.2010.09.099

✦ Synopsis

Kansuinone (1), a rearranged euphane triterpenoid containing a spiro [5,6] ring system, was isolated from the roots of Euphorbia kansui. Its structure and stereochemistry were elucidated on the basis of spectroscopic, CD, and computational methods. Kansuinone (1) exhibited inhibitory activity against human and mouse 11b-HSD1 (11b-hydroxysteroid dehydrogenase type 1), with IC 50 values of 1.12 and 1.08 lM, respectively.