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Kainic-acid induced neurotoxicity: Role of TNF-α

✍ Scribed by Zhang, Xing-Mei; Jie, Zhu

Book ID
123097981
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
53 KB
Volume
7
Category
Article
ISSN
1552-5260

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## Abstract The exact role of TNF‐α in excitotoxic neurodegeneration of the brain is unclear. To address this issue, the kainic acid (KA)–induced hippocampal injury model, a well‐characterized model of human neurodegenerative diseases, was used in TNF‐α receptor 1 (TNFR1)–knockout (TNFR1^−/−^) mice