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Kahakamides A and B, new neosidomycin metabolites from a marine-derived actinomycete

✍ Scribed by Robert W Schumacher; Beth L Harrigan; Bradley S Davidson

Publisher
Elsevier Science
Year
2001
Tongue
French
Weight
59 KB
Volume
42
Category
Article
ISSN
0040-4039

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✦ Synopsis

Two new indole nucleosides kahakamides A (1) and B (2) were isolated from the actinomycete Nocardiopsis dassonvillei, obtained from a shallow water sediment sample collected on the island of Kauai, Hawaii. Compounds 1 and 2 are related to the neosidomycin antibiotics, a group of rare indole-N-glycosides, and their structures were determined using spectroscopic methods. Compound 1 exhibited antimicrobial activity toward the Gram positive bacterium Bacillus subtilis.

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