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Kaempferol and quercetin isolated from Euonymus alatus improve glucose uptake of 3T3-L1 cells without adipogenesis activity

โœ Scribed by Xian-Kang Fang; Jie Gao; Dan-Ni Zhu


Book ID
116719322
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
580 KB
Volume
82
Category
Article
ISSN
0024-3205

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Among nine flavonols (1-9) obtained from Sophorae Flos, we first isolated compounds 4, 5, 8, and 9. These isolates (1-9) were evaluated for the phosphorylation of AMPK and ACC. Administered at 10 lM, 9 possessed high potent activity. Compound 9 displayed a dose-dependent stimulation of glucose uptak