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K-ras mutations in nonmucinous ovarian epithelial tumors : A molecular analysis and clinicopathologic study of 144 patients

✍ Scribed by Miriam Cuatrecasas; Nadina Erill; Eva Musulen; Irmgard Costa; Xavier Matias-Guiu; Jaime Prat

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 112 KB
Volume: 82
Category: Article
ISSN: 0008-543X
DOI: 10.1002/(sici)1097-0142(19980315)82:6<1088::aid-cncr12>3.0.co;2-2

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✦ Synopsis

BACKGROUND. To assess the putative

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tissue, and target sequences were amplified in vitro by polymerase chain reaction. lona, Spain. Mutations were detected by the presence of restriction fragment length polymorphisms artificially introduced by the use of mutant amplimers. In tumors containing areas that exhibited different histologic