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K-ras Mutations and Benefit from Cetuximab in Advanced Colorectal Cancer

✍ Scribed by Karapetis, Christos S.; Khambata-Ford, Shirin; Jonker, Derek J.; O'Callaghan, Chris J.; Tu, Dongsheng; Tebbutt, Niall C.; Simes, R. John; Chalchal, Haji; Shapiro, Jeremy D.; Robitaille, Sonia; Price, Timothy J.; Shepherd, Lois; Au, Heather-Jane; Langer, Christiane; Moore, Malcolm J.; Zalcberg, John R.


Book ID
120404544
Publisher
Massachusetts Medical Society
Year
2008
Tongue
English
Weight
460 KB
Volume
359
Category
Article
ISSN
0096-6762

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Genetic instability related to defective DNA mismatch repair genes may be involved in the pathogenesis of carcinoma in Hereditary Non-Polyposis Colorectal Cancer (HN-PCC). To test that the targets of genetic instability could include critical transforming genes involved in colon tumor progression, w