K-ras mutation in colorectal cancer: relations to patient age, sex and tumour location
β Scribed by Breivik, J; Meling, GI; Spurkland, A; Rognum, TO; Gaudernack, G
- Book ID
- 109837076
- Publisher
- Nature Publishing Group
- Year
- 1994
- Tongue
- English
- Weight
- 865 KB
- Volume
- 69
- Category
- Article
- ISSN
- 0007-0920
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π SIMILAR VOLUMES
Point mutations in codon 12, 13, and 61 of the K-ras gene are an early event in tumorigenesis of colorectal cancer, but the impact of number, type, and position of such mutations on the progression of adenomas as well as the clinical behaviour of colorectal carcinomas is not clearly established. A s
## Abstract Material from paraffin sections of 109 human colorectal carcinomas, mostly obtained at autopsy, was analyzed for the presence of Kβ__ras__ point mutations at codon 12, position 2. Mutations at this position were found in 23 cases (21.1%). Aneuploid colorectal carcinomas showed a signifi