K+ depletion and Na+ pump density
β Scribed by LAMB, J. F.; AITON, J. F.; OGDEN, PAT
- Book ID
- 109725670
- Publisher
- Nature Publishing Group
- Year
- 1982
- Tongue
- English
- Weight
- 252 KB
- Volume
- 295
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/295717c0
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Because high extracellular K+ concentrations (18-20 m ~) increased glial NaC-and K+-dependent adenosine triphosphatase {(Na' + K+)-ATPase} activities, while this increase was not observed in neuronal preparations, it is hypothesized that K+ released in the extracellular space during neuronal firing
## Abstract In Na^+^β and K^+^βfree solution, an inwardβdirected current can be detected in Xenopus oocytes, which is inhibited by cardic glycosides and activated by ATP. Therefore, it is assumed to be generated by the Na^+^, K^+^ pump. At negative membrane potentials, the pump current increases wi