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Juvenile myoclonic epilepsy: An autosomal recessive disease

✍ Scribed by Prof. Chrysostomos P. Panayiotopoulos; Tahir Obeid

Publisher: John Wiley and Sons
Year: 1989
Tongue: English
Weight: 399 KB
Volume: 25
Category: Article
ISSN: 0364-5134
DOI: 10.1002/ana.410250504

No coin nor oath required. For personal study only.

✦ Synopsis

We undertook genetic study of patients with juvenile myoclonic epilepsy (JME) from 17 families. There was a mean of 8 children in each sibship. Siblings were affected in 8 sibships, and some families had more than 2 members affected by JME. Half-siblings and parental involvement were found in only 1 sibship each. The segregation ratio was 0.123 but increased to 0.18 with correction for age of onset. Parental consanguinity was found in 9 (45%) of the sibships. The evidence establishes an autosomal recessive mode of inheritance for JME.

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