Juvenile hypertrophic osteoarthropathy associated with primary sclerosing cholangitis

✍ Scribed by Antonio J. Reginato; Robert Petrokubi; C. Alan Jasper

• Publisher: John Wiley and Sons
• Year: 1980
• Tongue: English
• Weight: 479 KB
• Volume: 23
• Category: Article
• ISSN: 0004-3591
• DOI: 10.1002/art.1780231212

✦ Synopsis

Hypertrophic osteoarthropathy has rarely been reported in children (1). Chronic lung disease has been the most commonly reported association in those series described during the preantibiotic era (1,2). Congenital cyanotic heart disease, biliary atresia, liver cirrhosis, metastatic lung tumor, and idiopathic cases with familial aggregation have been also seen in childhood (1-3). In some cases, arthritis may be very prominent and closely simulate the clinical picture of juvenile rheumatoid arthritis (1,2).

Reported here is a unique case of a teenage boy with idiopathic sclerosing cholangitis and hypertrophic osteoarthropathy, an association not described in the literature reviewed. He presented with spiking fever, jaundice, splenomegaly, and symmetrical arthritis of elbows, wrists, knees, and ankles mimicking juvenile rheumatoid arthritis.

CASE REPORT

In good health until November 1976, this 16year-old congenitally deaf black male sought medical aid because of daily spiking fever of several weeks duration. Physical examination was remarkable for icterus,