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Jumping translocations of the long arms of chromosome 1 in myeloid malignancies is associated with a high risk of transformation to acute myeloid leukaemia

โœ Scribed by Vesna Najfeld; Joseph Tripodi; Angela Scalise; Lewis R. Silverman; Richard T. Silver; Steven Fruchtman; Ronald Hoffman


Book ID
108676943
Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
151 KB
Volume
151
Category
Article
ISSN
0007-1048

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## Abstract __RUNX1__ (previously __AML1__) is involved in multiple recurrent chromosomal rearrangements in hematological malignances. Recently, we identified a novel fusion between __RUNX1__ and __LPXN__ from an acute myeloid leukemia (AML) patient with t(11;21)(q12;q22). This translocation genera