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Jumping translocations in hematological malignancies: a cytogenetic study of five cases

✍ Scribed by Kalliopi N. Manola; Vasileios N. Georgakakos; Chryssa Stavropoulou; Alexandros Spyridonidis; Maria K. Angelopoulou; Ioanna Vlachadami; Andreas Katsigiannis; Paraskevi Roussou; Gabriel E. Pantelias; Constantina Sambani

Book ID
113513414
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
566 KB
Volume
187
Category
Article
ISSN
0165-4608

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Many unbalanced translocations show dupl
Many unbalanced translocations show duplication of a translocation participant. Clinical and cytogenetic implications in myeloid hematologic malignancies
✍ Bent Pedersen; Jan M. NΓΈrgaard; Bjarne Bach Pedersen; Niels Clausen; Inge Helleb πŸ“‚ Article πŸ“… 2000 πŸ› John Wiley and Sons 🌐 English βš– 200 KB πŸ‘ 1 views

If a translocation is followed by loss of one of the two derivative chromosomes, the result is an unbalanced translocation, showing monosomy for the segments making up the lost derivative. We have found that in most unbalanced translocations, a third event takes place: a morphologically normal copy