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JPO1/CDCA7, a novel transcription factor E2F1-induced protein, possesses intrinsic transcriptional regulator activity

✍ Scribed by Yuya Goto; Reiko Hayashi; Tomoki Muramatsu; Hitomi Ogawa; Ikumi Eguchi; Yasuhiro Oshida; Kiyoshi Ohtani; Kenichi Yoshida

Book ID: 113485460
Publisher: Elsevier Science
Year: 2006
Tongue: English
Weight: 415 KB
Volume: 1759
Category: Article
ISSN: 0167-4781
DOI: 10.1016/j.bbaexp.2006.02.004

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## Abstract The E2F1 transcription factor can initiate proliferation or apoptosis, the latter by both transcription‐dependent and ‐independent mechanisms. Recently, an E2F1 mutant lacking the DNA binding domain, E2F1(180–437), has been implicated in degradation of MDMX and MDM2 proteins via lysosom