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Joint Genome-Wide Profiling of miRNA and mRNA Expression in Alzheimer's Disease Cortex Reveals Altered miRNA Regulation

✍ Scribed by Nunez-Iglesias, Juan; Liu, Chun-Chi; Morgan, Todd E.; Finch, Caleb E.; Zhou, Xianghong Jasmine; Maas, Stefan

Book ID: 120251172
Publisher: Public Library of Science
Year: 2010
Tongue: English
Weight: 355 KB
Volume: 5
Category: Article
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0008898

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## Abstract Alzheimer's disease (AD) is characterized by a complex neurodegenerative process affecting multiple genes and proteins in the neocortex, many of which have not been well‐studied. In this study, we investigated genome‐wide gene alterations in the temporal cortex of a well‐characterized c