Within a health-care environment of ever-increasing scrutiny and heightened expectations, nurses, physicians, public health scientists, and other health-care professionals must continually explore what works best in patient care based on the best evidence available. The goal of evidence-based practice (EBP) in nursing is to promote improved interventions, care, and patient outcomes. Johns Hopkins Nursing Evidence-Based Practice Model and Guidelines depicts three essential cornerstones that form the foundation for professional nursing: practice, education, and research. Nursing practice is the means by which a patient receives nursing care; education reflects the acquisition of the nursing knowledge and skills necessary to become a proficient clinician and to maintain competency; and research provides new knowledge to the profession and enables the development of practices based on scientific evidence. Nurses from The Johns Hopkins Hospital and faculty members from The Johns Hopkins University School of Nursing worked in collaboration to develop the practice model in this book. The model and guidelines demystify and facilitate the EBP process for administrators, managers, staff nurses, faculty, and students alike. The practical approach presented here puts EBP within the reach of every nurse and health-care institution.