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JNK promotes Bax translocation to mitochondria through phosphorylation of 14-3-3 proteins

โœ Scribed by Tsuruta, Fuminori; Sunayama, Jun; Mori, Yasunori; Hattori, Seisuke; Shimizu, Shigeomi; Tsujimoto, Yoshihide; Yoshioka, Katsuji; Masuyama, Norihisa; Gotoh, Yukiko

Book ID
110027608
Publisher
Nature Publishing Group
Year
2004
Tongue
English
Weight
243 KB
Volume
23
Category
Article
ISSN
0261-4189

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## Abstract The __tuberous sclerosis complex 2__ (__Tsc2__) gene product, tuberin, acts as a negative regulator of mTOR signaling, and loss of tuberin function leads to tumors of the brain, skin, kidney, heart, and lungs. Previous studies have shown that loss of tuberin function affects the stabili