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JNK is required for effector T-cell function but not for T-cell activation

โœ Scribed by Dong, Chen; Yang, Derek D.; Tournier, Cathy; Whitmarsh, Alan J.; Xu, Jie; Davis, Roger J.; Flavell, Richard A.


Book ID
109769492
Publisher
Nature Publishing Group
Year
2000
Tongue
English
Weight
183 KB
Volume
405
Category
Article
ISSN
0028-0836

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## JNK, but not MAPK, activation is associated with Fas-mediated apoptosis in human T cells Fas is a cell surface molecule that is expressed on a wide array of cell types and triggers apoptosis. While in most situations Fas ligation activates programmed cell death, on resting T lymphocytes it can