✦ LIBER ✦

JNK: A double-edged sword in tumorigenesis

✍ Scribed by Francisco Javier Cubero; Gang Zhao; Christian Trautwein

Publisher: John Wiley and Sons
Year: 2011
Tongue: English
Weight: 309 KB
Volume: 54
Category: Article
ISSN: 0270-9139
DOI: 10.1002/hep.24532

No coin nor oath required. For personal study only.

✦ Synopsis

The c-Jun NH2-terminal kinase (JNK) signal-transduction pathway has been implicated in the growth of carcinogeninduced hepatocellular carcinoma. However, the mechanism that accounts for JNK-regulated tumor growth is unclear. Here, we demonstrate that compound deficiency of the two ubiquitously expressed JNK isoforms (JNK1 and JNK2) in hepatocytes does not prevent hepatocellular carcinoma development. Indeed, JNK deficiency in hepatocytes increased the tumor burden. In contrast, compound JNK deficiency in hepatocytes and nonparenchymal cells reduced both hepatic inflammation and tumorigenesis. These data indicate that JNK plays a dual role in the development of hepatocellular carcinoma. JNK promotes an inflammatory hepatic environment that supports tumor development, but also functions in hepatocytes to reduce tumor development.

📜 SIMILAR VOLUMES

A Double-Edged Sword

✍ L.M. Somerton 📂 Fiction 📅 2014 🏛 Totally Bound Publishing 🌐 English ⚖ 102 KB 👁 3 views

*How do you stay standing when the ground is torn from beneath your feet?* Becket and Christian are taking the first, tentative steps towards the committed D/s relationship they both crave when the world literally explodes around them. In a frightening reversal of roles, Becket has to deal with his

Natalizumab: A double-edged sword?

✍ Lisa M. DeAngelis 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 42 KB 👁 1 views

Cyberknife: A double edged sword?

✍ Bindhu Joseph; Sanjay S. Supe; Aruna Ramachandra 📂 Article 📅 2010 🏛 Wielkopolskie Centrum Onkologii 🌐 Polish ⚖ 162 KB

The Cyberknife represents a new, frameless stereotactic radiosurgery system which efficiently incorporates advance robotics with computerized image reconstruction to allow highly conformal image guided radiation delivery. This review focus is on the pros and cons of this new radiotherapy tool, its c

Autophagy—A double-edged sword in oncolo

Autophagy—A double-edged sword in oncology

✍ Anja Apel; Hanswalter Zentgraf; Markus W. Büchler; Ingrid Herr 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 French ⚖ 184 KB

## Abstract Autophagy or “self‐eating” digests proteins and functionless cell organelles to reuse. This cell‐own recycling system attracts much attention in tumour biology. One of the major functions of autophagy is maintaining cellular homeostasis. Thus, it is constitutive active in all living cel

Erythropoietin and cancer, a double-edge

Erythropoietin and cancer, a double-edged sword

✍ Domenico Ribatti 📂 Article 📅 2009 🏛 Elsevier Science 🌐 English ⚖ 98 KB

NerveCenter: Are federal laboratory regu

NerveCenter: Are federal laboratory regulations a double-edged sword?

✍ Kathlyn Stone 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 261 KB 👁 1 views

## Improvements Act of 1988 (CLIA) established standards to improve the accuracy, reliability, and timeliness of patient test results. Although the standards were established to improve the process of delivering test results to patients, some suggest that CLIA regulations may be too restrictive an