JCP anniversary issue: Seventy-five years of milestones in cellular physiology

✍ Scribed by Gary S. Stein; Constance E. Brinckerhoff; Harvey M. Florman

• Publisher: John Wiley and Sons
• Year: 2007
• Tongue: English
• Weight: 60 KB
• Volume: 213
• Category: Article
• ISSN: 0021-9541
• DOI: 10.1002/jcp.21287

✦ Synopsis

This year marks the 75th anniversary for Journal of Cellular Physiology. The longstanding effectiveness of the Journal reflects its pivotal role in providing a forum for publication of major contributions that reflect spectacular progress in fundamental biological and biomedical research during the past 75 years. Beginning with the inaugural issue in 1932, Journal of Cellular Physiology has featured important advances in our understanding of biological processes, and new approaches that have led to more effective diagnosis and treatment of human disease.

Cellular physiology as a discipline and the Journal have facilitated the evolution of mechanistic insights into regulatory mechanisms that govern proliferation, cell cycle control, cell growth and differentiation. In addition, the Journal has promoted the publication of information on the integration of signaling cascades that mediate development, cell motility, cell adhesion, fertilization, embryogenesis and gametogenesis. Cellular physiology has also been instrumental in establishing mechanistic parameters of perturbed regulation that are associated with transformation and tumorigenesis, as well as with a broad spectrum of diseases that include but are not confined to renal, cardiovascular, neural, endocrine and musculoskeletal systems. Now, in the 21st century, cellular physiology is transitioning from the identification and functional characterization of physiological mediators at the cellular level to pursuit of physiological control from molecular, cellular and in vivo genetic perspectives. Emphasis is on combinatorial control that is associated with the dynamic organization, assembly and integration of regulatory networks that support cell structure, communication, function and activity. Consistent with these new dimensions to the field, Journal of Cellular Physiology is committed to publishing research that utilizes genomics, proteomics, and bioinformatics.

To celebrate our 75 year legacy and most importantly, to project ahead, we have developed a series of mini-reviews that highlight emerging concepts, experimental strategies and components of physiological control that are providing platforms for novel insight into biology and pathology. It would be unrealistic to be comprehensive and inclusive. However, we are confident that the 75th anniversary mini-review series that will appear in this and the next several issues of the Journal will illustrate opportunities for furthering our understanding of molecular mechanisms controlling biology, and build on paradigms provided by cellular physiology.