JC virus induces a vigorous CD8+ cytotoxic T cell response in multiple sclerosis patients
β Scribed by Renaud A. Du Pasquier; Marion C. Stein; Marco A. Lima; Xin Dang; Jims Jean-Jacques; Yue Zheng; Norman L. Letvin; Igor J. Koralnik
- Book ID
- 113729841
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 163 KB
- Volume
- 176
- Category
- Article
- ISSN
- 0165-5728
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In order to explore the T-cell repertoire to myelin basic protein (BP) of both multiple sclerosis (MS) patients and healthy subjects (HS), we raised BP reactive T-cell lines from blood mononuclear cells of eight MS patients and five HS. These lines were triggered in vitro by human BP. When analyzing