## Abstract The JC virus (JCV) is a common human virus persisting in renal tissue. In immunocompromised individuals it may reactivate and cause progressive multifocal leukoencephalopathy (PML). JCV has also been implicated in cancerogenesis, leading to various brain tumors and cancers of gastrointe
JC virus genotyping offers a new paradigm in the study of human populations
β Scribed by Yoshiaki Yogo; Chie Sugimoto; Huai-Ying Zheng; Hiroshi Ikegaya; Tomokazu Takasaka; Tadaichi Kitamura
- Publisher
- John Wiley and Sons
- Year
- 2004
- Tongue
- English
- Weight
- 285 KB
- Volume
- 14
- Category
- Article
- ISSN
- 1052-9276
- DOI
- 10.1002/rmv.428
No coin nor oath required. For personal study only.
β¦ Synopsis
Abstract
A small DNA virus, named JC virus (JCV) and belonging to the Polyomaviridae, is attracting the attention of anthropologists worldwide, as JCV genotyping appears to be a novel means of elucidating human migrations and the origins of various ethnic groups. The basic properties of JCV, the regional distributions of JCV genotypes, and the phylogenetic relationships among various JCV genotypes are described. Then, a study is described in which the origin of the modern Japanese was extensively investigated using the JCV genotyping method. Based on JCV genotypes in neighboring areas, the origins of people who carried JCV genotypes to the Japanese Archipelago are discussed. Finally, the relationships between JCV genotypes and Yβchromosome haplogroups are examined, as genetic variation on the Y chromosome has recently been examined in detail to investigate ancient human migrations and the population structures of human groups. Copyright Β© 2004 John Wiley & Sons, Ltd.
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