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Jak2 and Tyk2 are necessary for lineage-specific differentiation, but not for the maintenance of self-renewal of mouse embryonic stem cells

✍ Scribed by Bo Mee Chung; Ho Chul Kang; Su Youne Han; Hyen Seok Heo; Jong Joo Lee; Jinseon Jeon; Ji Young Lim; Incheol Shin; Seung Hwan Hong; Yoon Shin Cho; Chul Geun Kim


Book ID
116293846
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
783 KB
Volume
351
Category
Article
ISSN
0006-291X

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## Abstract Self‐renewal of pluripotent human embryonic stem (hES) cells utilizes an abbreviated cell cycle that bypasses E2F/pRB‐dependent growth control. We investigated whether self‐renewal is alternatively regulated by cyclin/CDK phosphorylation of the p220^NPAT^/HiNF‐P complex to activate __hi