J7 3:45 Immunoglobulin heavy chain expression in the turtle (Pseudemys scripta elegans)

In a model of immunoglobulin heavy-chain

In a model of immunoglobulin heavy-chain (IGH)/MYC translocation, the Igh 3′ regulatory region induces MYC expression at the immature stage of B cell development

✍ Yi Yan; Sung Sup Park; Siegfried Janz; Laurel A. Eckhardt 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 361 KB

## Abstract Reciprocal translocations involving the immunoglobulin loci and the cellular oncogene __MYC__ are hallmark mutations of the human postgerminal center B cell neoplasm, Burkitt's lymphoma. They are occasionally found in other B cell lymphomas, as well. Translocations involving the heavy c