𝔖 Bobbio Scriptorium
✦   LIBER   ✦

J-difference lactate editing at 3.0 Tesla in the presence of strong lipids

✍ Scribed by Mari A. Smith; Jason A. Koutcher; Kristen L. Zakian

Book ID
102374461
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
435 KB
Volume
28
Category
Article
ISSN
1053-1807

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✦ Synopsis

Abstract

Purpose

To implement in vivo detection of lactate in the presence of lipids by proton magnetic resonance spectroscopy at a 3 Tesla (T) field strength for potential applications in human tumors outside of the brain.

Materials and Methods

The BASING J‐difference sequence was implemented in the presence of high lipid concentrations in phantoms and in vivo at 3 Tesla.

Results

The effectiveness of the lactate editing scheme is demonstrated in phantoms containing both lactate and lipids and in vivo in ischemic induced human muscle.

Conclusion

The ability of the BASING J‐difference technique to detect lactate in the presence of strong lipid signals outside the brain at 3T is feasible. This robust technique should permit noninvasive lactate measurements in human tumors to investigate its potential as a prognostic indicator. J. Magn. Reson. Imaging 2008;28:1492–1498. © 2008 Wiley‐Liss, Inc.

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