𝔖 Bobbio Scriptorium
✦   LIBER   ✦

IκB kinase inhibitors for treating autoimmune and inflammatory disorders: potential and challenges

✍ Scribed by Joann Strnad; James R. Burke

Book ID
116918693
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
642 KB
Volume
28
Category
Article
ISSN
0165-6147

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Obesity is associated with chronic low-grade inflammation that negatively impacts insulin sensitivity. Here, we show that high-fat diet can increase NF-B activation in mice, which leads to a sustained elevation in level of IB kinase ⑀ (IKK⑀) in liver, adipocytes, and adipose tissue macrophages. IKK⑀