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Ivermectin distribution in the plasma and tissues of patients infected with Onchocerca volvulus

✍ Scribed by O. Z. Baraka, B. M. Mahmoud, C. K. Marschke…

Book ID
120759471
Publisher
Springer
Year
1996
Tongue
English
Weight
257 KB
Volume
50
Category
Article
ISSN
0031-6970

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Ivermectin, at the standard dose of 150 cLg/kg bodyweight, does not kill the adult worms of Onchocerca volvulus and does not disrupt embryogenesis or spermatogenesis. Repeated standard doses, if maintained, arrest microfilarial production but result in only a mild-to-modest macrofilaricidal effect.