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Itch E3 Ligase-Mediated Regulation of TGF-β Signaling by Modulating Smad2 Phosphorylation

✍ Scribed by Yongli Bai; Chun Yang; Kathrin Hu; Chris Elly; Yun-Cai Liu

Book ID
116753605
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
268 KB
Volume
15
Category
Article
ISSN
1097-2765

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## Abstract Transforming growth factor‐β (TGF‐β) signaling is known to depend on the formation of Smad2/3‐Smad4 transcription regulatory complexes. However, the signaling functions of Smad2/3‐Smad4 during TGF‐β‐induced responses are obscure as TGF‐β also initiates a number of other signaling pathwa