It All Began with an Error: The Nomofungin/Communesin Story

✍ Scribed by Peter Siengalewicz; Tanja Gaich; Johann Mulzer

• Publisher: John Wiley and Sons
• Year: 2008
• Tongue: English
• Weight: 439 KB
• Volume: 47
• Category: Article
• ISSN: 0044-8249
• DOI: 10.1002/anie.200801735

✦ Synopsis

Abstract

The communesin/nomofungin/perophoramidine story is an impressive example of how biogenetic considerations can lead to the correction of structural misassignments and inspire synthetic chemists with new, fruitful ideas. Intensive studies by a number of research groups culminated in the total synthesis of perophoramidine by the Funk research group in 2004. In 2007, Qin and co‐workers completed the first total synthesis of a communesin.