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Isozyme pattern of fructose diphosphate aldolase during hepatocarcinogenesis induced by 2-acetylaminofluorene in rat liver

✍ Scribed by Dr. Danuta Silber; Ewa Checinska; Jerzy Rabczynski; Marian Kochman

Publisher
John Wiley and Sons
Year
1975
Tongue
French
Weight
654 KB
Volume
16
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

The biosynthesis of aldolase A and B subunits has been studied in rat liver during the administration of carcinogen AAFThe abbreviations used in this paper are: FDP — fructose‐1,6‐diphosphate; F‐1‐P — fructose‐1‐phosphate; AAF — 2‐acetylaminofluorenea

. Transition from a predominance of aldolase B to A was observed during carcinogenesis in rat liver. Changes in isozymic pattern and FDP to F‐1‐P cleavage activity ratio were observed before histological alterations typical of hepatoma could be detected. Our data support the hypothesis of dedifferentiation during hepatocarcinogenesis which in an early stage results in switching on of the gene for aldolase A with simultaneous continuation of biosynthesis of aldolase B within single cells.

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Evidence of two separate mechanisms for the decrease in aryl sulfotransferase activity in rat liver during early stages of 2-acetylaminofluorene–induced hepatocarcinogenesis
✍ David P. Ringer; Boyd A. Howell; Tom R. Norton; Gary W. Woulfe; Michael W. Duffe 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 English ⚖ 691 KB

## Abstract Enzymatic and immunohistochemical experiments were conducted to evaluate the mechanistic basis for the downregulation of the important detoxication/bioactivation enzyme aryl sulfotransferase IV (AST IV) during 2‐ acetylaminofluorene (2AAF)–induced hepatocarcinogenesis. To distinguish be