Isovolemic hemodilution–red cell exchange for prevention of cerebrovascular accident in sickle cell anemia: The standard operating procedure

Advantages of isovolemic hemodilution-re

Advantages of isovolemic hemodilution-red cell exchange therapy to prevent recurrent stroke in sickle cell anemia patients

✍ Ravi Sarode; Karén Matevosyan; Zora R. Rogers; James D. Burner; Cynthia Rutherfo 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 125 KB

## Abstract Chronic simple hypertransfusion (every 3 to 4 weeks) effectively prevents secondary stroke in children with sickle cell anemia but leads to iron overload despite chelation therapy. Conventional red blood cell exchange (C‐RBCx) has advantages over simple transfusion: no net iron gain and