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Isovalerylcarnitine is a specific activator of the high calcium requiring calpain forms

✍ Scribed by S. Pontremoli; E. Melloni; P.L. Viotti; M. Michetti; F. Di Lisa; N. Siliprandi


Book ID
115763527
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
472 KB
Volume
167
Category
Article
ISSN
0006-291X

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Regulation of the mM-calcium-requiring form of calpain (m calpain) was studied in SH-SY-5Y human neuroblastoma cells. Immunoblot analysis demonstrated that the vast majority of m calpain is localized within cytosolic pools. Calpain activation was monitored as a function of autolysis within intact ce