Isotypic pattern of the polyclonal B cell response during primary infection by Plasmodium chabaudi and in immune-protected mice
✍ Scribed by Pierre Barthélémy Falanga; Maria Regina D'imperio Lima; Antonio Coutinho; Luiz Pereira Da Silva
- Publisher
- John Wiley and Sons
- Year
- 1987
- Tongue
- English
- Weight
- 476 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0014-2980
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✦ Synopsis
Isotypic pattern of the polyclonal B cell response during primary infection by Plasmodium chabaudi and in immune-protected mice*
The primary infection by P. chabaudi induces an increase of the numbers of splenic immunoglobulin (1g)-secreting B cells in both athymic and euthymic BALBic mice. The isotypic pattern of the polyclonal response is restricted only in euthymic mice where IgG2,, IgG2b and IgM plaque-forming cells (PFC) predominate. In immunized animals, protected against a parasite challenge, the isotypic pattern of splenic PFC is completely different, the IgGl and IgM isotypes constituting the main part of the response. Reinoculation of immune-protected animals induces a PFC response which is dose dependent and accentuates the characteristic isotypic profile of the immuneprotected mice.