Isotopic Estimation of the Hepatic Glucose Balance in vivo

✍ Scribed by Robert Rognstad

• Book ID: 102977057
• Publisher: Elsevier Science
• Year: 1994
• Tongue: English
• Weight: 687 KB
• Volume: 168
• Category: Article
• ISSN: 0022-5193
• DOI: 10.1006/jtbi.1994.1096

✦ Synopsis

Conventional determination of "hepatic glucose production" in the refed state is based on the 30-year-old Steele model, which omits glucose<-->glucose-6P cycling. Using the more complete model, conventional hepatic glucose production is shown to be a complex ratio of fluxes, and not a simple physiological flux. Our new model allows some prospective isotopic approaches to the estimation of glucose-6-phosphatase and glucokinase fluxes, and thus real net hepatic glucose production or uptake.