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Isotope labeled ‘HEA Moiety’ in the synthesis of labeled HIV-protease inhibitors – Part 1

✍ Scribed by I. Victor Ekhato; Yuan Liao; Mihaela Plesescu

Publisher
John Wiley and Sons
Year
2004
Tongue
French
Weight
176 KB
Volume
47
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

[(S)‐1′‐((N‐tert‐Butyloxycarbonyl)amino)‐2S‐[^2^H~5~]phenyl‐ethyl]oxirane 11, made from [^2^H~5~]‐bromobenzene, was transformed into the HIV‐protease inhibitors [^2^H~5~]‐DPH 153893 and [^2^H~5~]‐DPH 140662. Both compounds are members of the hydroxyethylamine class of protease inhibitors (HIV‐PIs). The method of synthesis is applicable to members of this class and the HEE group of HIV‐PIs. Copyright © 2004 John Wiley & Sons, Ltd.

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