✍ Scribed by Poul Erik Hansen
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An overview of recent developments in the use of isotope effects in hydrogen‐bonded systems with special emphasis on intramolecular hydrogen bonding is given. The systems investigated cover both resonance‐assisted hydrogen bonded (RAHB) and non‐RAHB systems. Deuterium isotope effects on ^13^C chemical shifts are discussed extensively together with effects on ^1^H, ^19^F and ^15^N chemical shifts. The compounds cover a large range from hydrogen‐bonded esters over amides, thioamides, Schiff bases also covering proteins, nucleic acids and carbohydrates. Isotope effects are discussed both in static and tautomeric systems and in the liquid and solid states. Theoretical approaches to isotope effects on chemical shifts are likewise treated. Copyright © 2007 John Wiley & Sons, Ltd.
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The intramolecular H-bond strength in cis-enolic forms of b-diketones was investigated. The correlations between the 'H hydroxyl proton shieldings and the chemical shifts of the "C and "0 nuclei involved in the chelate ring, and the H/D isotope shifts on the latter resonances, were determined. An in
17O chemical shifts were measured in 40 enamines activated in the b-position by CxO, COO, NO 2 , SO and groups. Data for the oxygen-containing series of o-hydroxyacyl aromatics are also included for com-SO 2 parison. Intramolecular hydrogen bonding in the enamines is discussed in terms of the accept
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