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Isotope dilution analysis of methylcitric acid in amniotic fluid for the prenatal diagnosis of propionic and methylmalonic acidemia

✍ Scribed by Gordon Naylor; Lawrence Sweetman; William L. Nyhan; Cecil Hornbeck; John Griffiths; Lars Mörch; Svante Brandänge

Book ID
115823300
Publisher
Elsevier Science
Year
1980
Tongue
English
Weight
725 KB
Volume
107
Category
Article
ISSN
0009-8981

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Improved prenatal diagnosis of methylmal
Improved prenatal diagnosis of methylmalonic acidemia: Mass fragmentography of methylmalonic acid in amniotic fluid and maternal urine
✍ F. K. Trefz; H. Schmidt; B. Tauscher; E. Depène; R. Baumgartner; G. Hammersen; W 📂 Article 📅 1981 🏛 Springer 🌐 English ⚖ 452 KB

A sensitive and reliable method for trace analysis of methylmalonic acid in amniotic fluid and urine is described using deuterated methyhnalonic acid as the internal standard and capillary gas chromatography/mass fragmentography. The application of the method for the prenatal diagnosis of methylmalo