## Abstract Modulation of the Ca^2+^ sensitivity and cooperativity of secretion is an important means of regulating neurotransmission and hormone secretion. Employing highβtime resolution measurement of membrane capacitance (Cm) stimulated by stepβlike or ramp [Ca^2+^]~i~ elevation, we have identif
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Isothiocyanates sensitize the effect of chemotherapeutic drugs via modulation of protein kinase C and telomerase in cervical cancer cells
β Scribed by Sutapa Mukherjee; Shubhabrata Dey; R. K. Bhattacharya; Madhumita Roy
- Publisher
- Springer
- Year
- 2009
- Tongue
- English
- Weight
- 452 KB
- Volume
- 330
- Category
- Article
- ISSN
- 0300-8177
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Derivatives of camptothecins, topoisomerase I inhibitors and 7-hydroxystaurosporine (UCN-01), a protein kinase C (PKC) inhibitor and cell cycle checkpoint abrogator, are promising anticancer drugs. We characterized the apoptotic response to camptothecin and UCN-01 for the 8 human breast carcinoma ce