A series of azulene-based derivatives were synthesized as potent inhibitors for receptor tyrosine kinases such as FMS-like tyrosine kinase 3 (FLT-3). Systematic side chain modification of prototype 1a was carried out through SAR studies. Analogue 22 was identified from this series and found to be on
β¦ LIBER β¦
Isothiazolopyrimidines and Isoxazolopyrimidines as Novel Multi-Targeted Inhibitors of Receptor Tyrosine Kinases.
β Scribed by Zhiqin Ji; et al. et al.
- Publisher
- John Wiley and Sons
- Year
- 2006
- Weight
- 26 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0931-7597
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