Gas chromatographic and mass spectrometr
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K. K. Midha; D. V. C. Awang; I. J. McGilveray; J. Kleber
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Article
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1976
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John Wiley and Sons
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English
β 657 KB
Gas chromatographic analysis of the products of reaction of diazomethane with tolbutamide and chlorpropamide indicates the formation of three compounds in both cases. As expected, N-methylation (at sulfonamide nitrogen) is the predominant reaction; minor amounts of O-methylated product are also obse