Isosinococuline, a novel antitumor morphinane alkaloid from Cocculus trilobus

✍ Scribed by Hideji Itokawa; Kunihiko Nishimura; Yukio Hitotsuyanagi; Koichi Takeya

• Publisher: Elsevier Science
• Year: 1995
• Tongue: English
• Weight: 128 KB
• Volume: 5
• Category: Article
• ISSN: 0960-894X
• DOI: 10.1016/0960-894x(95)00123-b

✦ Synopsis

An antitumor alkaloid, isosinococuline 2, has been isolated from the rhizomes of Cocculus trilobus.

Its structure was elucidated by spectroscopic methods and chemical reactions.

We have previously reported the isolation and the structure elucidation of an antitumor alkaloid, sinococuline (1), as an active principle of the native Japanese plant Cocculus trilobus. 1 Since alkaloid 1 shows promising antitumor activity against animal tumor models, we have further investigated this plant to identify the active congeners. An intensive search of the methanol extract of the rhizomes of this plant led to the isolation of