Isoselenocyanates derived from amino acid esters: an expedient synthesis and application to the assembly of selenoureidopeptidomimetics, unsymmetrical Selenoureas and selenohydantoins
✍ Scribed by Hosahalli P. Hemantha; Vommina V. Sureshbabu
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 167 KB
- Volume
- 16
- Category
- Article
- ISSN
- 1075-2617
- DOI
- 10.1002/psc.1276
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
An important class of organoselenium compounds‐α‐isoselenocyanato esters 4 hasbeen prepared by a reaction of α‐isocyano esters with elemental selenium powder. The reaction issimple, rapid and all the isoselenocyanates havebeen isolated as stable ones after chromatographic purification. These hitherto unreported classes of molecules would be useful building blocks for the preparation of variety of selenium containing peptidomimetics. In this study, the utility of the title molecules in the preparation of selenoureidopeptidomimetics 6, unsymmetrical selenoureas 8 and selenohydantoins 10 isdemonstrated. Copyright © 2010 European Peptide Society and John Wiley & Sons, Ltd.