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Isoquinolin-1(2H)-ones and 1,6-naphthyridin-5(6H)-ones by an N-acylation-SNAr sequence

✍ Scribed by Bunce, Richard A.; Nammalwar, Baskar; Gnanasekaran, Krishna Kumar; Cain, Nicholas R.

Book ID
121471764
Publisher
Elsevier Science
Year
2014
Tongue
French
Weight
531 KB
Volume
70
Category
Article
ISSN
0040-4020

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## Abstract Vilsmeier formylation of the 4‐amino‐2‐pyridinones 4a–d leads to the formation of the corresponding 3‐carbaldehydes 5a–d (the diformylated product 8 is isolated as a by‐product). A cyclizing Knoevenagel reaction of 5 with CH‐acidic nitriles 6 in the presence of piperidine gives substitu